Elder Care (Everybody)

A minimally invasive treatment that blocks inflammation-driving blood vessels in the knee provided significant pain relief and improved function for osteoarthritis patients, with benefits lasting at least a year. The procedure was safe, highly successful, and could offer a new alternative for people seeking relief before considering knee replacement.

Diabetes and dementia appear to be closely intertwined, with each condition potentially influencing the other. Problems with insulin and glucose can affect the brain’s energy supply, increase inflammation, and damage blood vessels linked to memory loss. Researchers are also finding that some popular diabetes medications may lower dementia risk. These discoveries are opening new possibilities for protecting brain health as people age.

A copper-based compound restored the brain’s ability to clear toxic Alzheimer’s proteins, dramatically reducing amyloid buildup and improving memory in laboratory experiments. The findings point to a potentially fast-tracked new treatment strategy because the drug has already been tested in humans for other neurological conditions.

A new international study finds that middle-aged Americans are lonelier, more depressed, and experiencing worse memory and health than earlier generations. Researchers say growing financial strain, weaker social supports, and chronic stress may explain why the U.S. is falling behind other wealthy nations.

Researchers discovered that mutations linked to blood cancers may help trigger Alzheimer’s disease by creating overly inflammatory immune cells in the brain. The unexpected finding could lead to new blood-based screening methods and potential treatments borrowed from cancer medicine.

A new treatment that blocks an aging-related protein restored lost cartilage in old mice and helped prevent arthritis after knee injuries. Human cartilage samples showed similar signs of regeneration, raising hopes for a future drug that could repair joints instead of replacing them.

A major study suggests glucosamine, a popular supplement for joint pain, could be linked to faster progression from mild cognitive impairment to Alzheimer’s disease. Researchers found a 25% higher likelihood of developing dementia among glucosamine users and uncovered biological clues that may explain why.

A study of more than 2,100 adults found that eating more ultra-processed foods was linked to poorer attention and slower mental processing, even among people with otherwise healthy diets. Researchers also found higher consumption was associated with increased dementia risk factors, raising concerns about the hidden cognitive costs of heavily processed foods.

The largest review ever conducted on opioids for acute pain found that these widely prescribed drugs often deliver only small, short-lived benefits. For many common conditions, including some surgeries and kidney stone pain, opioids performed no better than a placebo. Researchers also found higher rates of side effects and warned that dependence can begin after only a short period of use.

Researchers have identified a new Alzheimer’s target and created an experimental compound that blocks a damaging process inside brain cells. In mice, the treatment slowed nerve cell loss, reduced Alzheimer’s-related changes, and even appeared to promote healthier aging.

A promising new study suggests rheumatoid arthritis may not be as inevitable as once thought for people at high risk. Researchers found that just one year of treatment with the immune-targeting drug abatacept delayed the onset of rheumatoid arthritis by up to four years, with benefits lasting long after treatment ended.

Scientists at Scripps Research have uncovered a molecular “switch” that appears to fuel the damaging brain inflammation seen in Alzheimer’s disease. They found that a protein called STING becomes chemically altered in a way that keeps the brain’s immune system stuck in overdrive, harming the connections between nerve cells.

Scientists at Stanford may have uncovered a hidden reason our brains decline with age. Studying the ultra-short-lived turquoise killifish, researchers discovered that the cellular machinery responsible for building proteins begins to jam and malfunction over time. Tiny structures called ribosomes start colliding and stalling while reading genetic instructions, triggering a chain reaction that leads to faulty proteins and harmful clumps linked to diseases like Alzheimer’s.

A sweeping global study found that chronic kidney disease now affects nearly 800 million people and has become one of the world's leading causes of death. Often silent in its early stages, the condition is also a major contributor to heart disease and may be even more common than current estimates suggest.

CBD may be doing far more than just easing pain or anxiety — new research suggests it could help fight Alzheimer’s disease by calming the brain’s runaway immune response. In experiments using Alzheimer’s mice, scientists found that inhaled CBD reduced key drivers of neuroinflammation, a damaging process increasingly linked to memory loss and brain degeneration.