Elder Care (Everybody)

Alcohol-related deaths in the U.S. nearly doubled from 1999 to 2020. The sharpest spike occurred among 25- to 34-year-olds (nearly fourfold), while individuals aged 55 to 64 had the highest rates. Men consistently had higher rates but women saw the largest proportional rise, with deaths increasing 2.5 times. Asian and Pacific Islander communities experienced the steepest ethnic increase, while the Midwest saw the greatest regional rise (2.5 times), followed by the Northeast, West, and South.

Researchers have linked disease-related proteins and genes to identify specific cellular pathways responsible for Alzheimer's genesis and progression. The proteins were gathered from cerebrospinal fluid and are a good proxy for activity in the brain. Several of them may be potential targets for therapies.

Recent advances in bladder cancer treatments may offer hope of curative care to more patients, including those with high-risk localized, muscle-invasive disease, according to a new editorial.

A new study by medicine safety experts found the use of gabapentinoids -- medicines widely used to treat neuropathic pain -- increased the risk of hip fractures, especially in older patients who were frail or had kidney disease.

People with conditions or habits such as high blood pressure, an irregular heartbeat called atrial fibrillation, or smoking, not only have a higher risk of stroke, they may also have more severe strokes than people without these risk factors.

A practical calculator predicts the risk of epilepsy after venous stroke. The aim is to improve care for those affected, which are predominantly young adults.

Researchers have identified a potential biomarker of Parkinson's disease progression. According to the new study, patients with a slow progression of the pathology would have a significant increase in the levels of a molecule called ecto-GPR37 in the cerebrospinal fluid.

A research team has shown that that combining pembrolizumab, an immunotherapy drug, with standard chemotherapy can improve treatment outcomes for patients with small cell bladder cancer and small cell/neuroendocrine prostate cancer.

Slightly overweight stroke survivors have a lower risk of sustaining disabilities. New research adds another aspect to the obesity paradox but also highlights the importance of considering the population's normal when recommending best practices.

Researchers found that a 12-week therapeutic virtual yoga program for chronic low back pain can be a feasible, safe and effective treatment option.

New research suggests older adults wait 3-6 months after a heart attack before elective noncardiac surgery to reduce the risk of serious complications like stroke or another heart attack.

Researchers published a study examining symptoms, health outcomes, and physical function over time in older adults with and without Alzheimer's disease and related dementias and polypharmacy.

A study has revealed a significant genetic risk factor for kidney disease in people from Ghana and Nigeria. Their study demonstrated that having just one risk variant in a gene known as APOL1 can significantly increase the risk of developing kidney disease. APOL1 is important for the immune system and variants of the gene are linked to increased risk of chronic kidney disease. The study is published in the New England Journal of Medicine and was conducted by researchers from the Human Heredity and Health in Africa (H3Africa) Kidney Disease Research Network.

Researchers studied what happens immediately after a stroke in the stem cell niche known as the subventricular zone, using a mouse model. This revealed a mechanism that results in fewer newborn neurons from the stem cell niche surviving after stroke, thereby significantly limiting the neurogenic reaction of the subventricular zone to repair the brain. This fundamental understanding of the cellular processes in the brain could help in future to boost the body's own repair to replace lost neurons and ameliorate the consequences of stroke.

Researchers have found that semaglutide may lower the risk of Alzheimer's disease in people with type 2 diabetes (T2D).