Elder Care (Everybody)

Researchers have designed a peptide that prevents the deadly misfolding of alpha-synuclein, the protein behind Parkinson’s and some dementias. In lab and animal tests, it stabilized the protein and improved motor function. The work demonstrates the power of rational drug design in tackling brain diseases that have long lacked effective treatments.

A new pill called baxdrostat may offer hope for people whose blood pressure stays high even after taking standard medications. In a recent study, the drug lowered blood pressure and also seemed to protect the kidneys by reducing signs of damage. Doctors say this could help millions of people with chronic kidney disease, a condition that often makes blood pressure harder to control.

Scientists have discovered that DMT, a natural compound found in plants and even the human brain, can dramatically reduce brain damage caused by stroke. The psychoactive molecule, long known for its hallucinogenic effects, restored the blood-brain barrier and reduced inflammation in animal and cell studies. These findings suggest that DMT could complement existing stroke treatments, potentially transforming recovery outcomes.

A University of New Mexico scientist is revealing what might be one of the most overlooked causes of dementia — damage in the brain’s tiny blood vessels. Dr. Elaine Bearer has created a new way to classify these changes, showing that many people diagnosed with Alzheimer’s also suffer from vascular damage that quietly destroys brain tissue. Even more surprising, she’s finding microplastics inside the brain that appear linked to inflammation and memory loss.

Researchers uncovered a key cellular regulator, PP2A-B55alpha, that controls both the cleanup of damaged mitochondria and the creation of new ones. In Parkinson’s disease models, reducing this regulator improved symptoms and mitochondrial health. The findings could inspire new drugs for Parkinson’s, mitochondrial disorders, and even cancer.

New research from Houston Methodist reveals how obesity may directly drive Alzheimer’s disease. Scientists discovered that tiny messengers released by fat tissue, called extracellular vesicles, can carry harmful signals that accelerate the buildup of amyloid-β plaques in the brain. These vesicles even cross the blood–brain barrier, making them powerful but dangerous connectors between body fat and brain health.

A massive nationwide study has linked long-term exposure to the industrial chemical trichloroethylene (TCE) with a higher risk of Parkinson’s disease in older adults. Researchers examined over 1.1 million people, finding that those living in areas with the highest outdoor TCE levels faced a 10% greater risk of developing Parkinson’s.

Penn researchers found that psilocybin can calm brain circuits tied to pain and mood, easing both physical suffering and emotional distress in animal studies. The compound works in the anterior cingulate cortex, bypassing injury sites and offering a dual benefit for pain and depression. Unlike opioids, psilocybin is non-addictive and may provide relief lasting weeks.

Scientists discovered that high-fat junk food disrupts memory circuits in the brain almost immediately. Within just four days, neurons in the hippocampus became overactive, impairing memory. Restoring glucose calmed the neurons, showing that interventions like fasting or dietary shifts can restore brain health. This could help prevent obesity-related dementia and Alzheimer’s.

Living with a sense of purpose may not just enrich life, it could also guard against dementia. A UC Davis study tracking over 13,000 adults for up to 15 years found that people with higher purpose were about 28% less likely to develop cognitive impairment. Purpose was linked to resilience across ethnicities, even in those with genetic risks for Alzheimer’s, and activities like relationships, volunteering, spirituality, and personal goals can help nurture it.

Researchers in Japan discovered that Parkinson’s patients diagnosed in their 80s are far more likely to show signs of amyloid buildup, a hallmark of Alzheimer’s, even without dementia symptoms. The study compared younger and older patients, finding that older individuals had three times the rate of amyloid positivity. Surprisingly, Parkinson’s patients overall showed lower amyloid buildup than healthy people their age, suggesting that Parkinson’s might change the way Alzheimer’s-related processes unfold in the brain.

Scientists have discovered a way to block pain while still allowing the body’s natural healing to take place. Current painkillers like ibuprofen and aspirin often come with harmful side effects because they shut down both pain and inflammation. But this new research identified a single “pain switch” receptor that can be turned off without interfering with inflammation, which actually helps the body recover.

For decades, scientists believed Alzheimer’s was driven mainly by sticky protein plaques and tangles in the brain. Now Purdue researchers have revealed a hidden culprit: fat. They found that brain immune cells can become clogged with fat, leaving them too weak to fight off disease. By clearing out this fat and restoring the cells’ defenses, researchers may have uncovered an entirely new way to combat Alzheimer’s — shifting the focus from plaques alone to how the brain handles fat.

A new study has revealed that TSPO, a protein linked to brain inflammation, rises long before Alzheimer’s symptoms appear. Researchers tracked the protein in genetically engineered mice and confirmed the results in human brain tissue from Colombian families with a known Alzheimer’s mutation. They found unusually high levels of TSPO in microglia clustered around plaques, particularly in women. This discovery not only deepens our understanding of the disease but also sparks the possibility of using TSPO to detect and treat Alzheimer’s far earlier than ever before.

A sweeping review from NYU Langone Health reveals that everyday exposure to plastics—especially during childhood—poses lasting risks for heart disease, infertility, asthma, and even brain development issues. These chemicals, found in packaging, cosmetics, and common household items, can disrupt hormones, ignite chronic inflammation, and lower IQ.