Elder Care (Everybody)

Virginia Tech researchers are investigating how overloaded mitochondria in the brain’s memory circuits may spark early Alzheimer’s damage. Their work focuses on calcium signaling and how it might trigger breakdowns in the entorhinal cortex.

Japanese scientists have developed ADRIANA, a non-opioid painkiller that could provide powerful relief without the dangers of addiction. With successful trials already completed, large U.S. studies are now underway, raising hopes for a safer future in pain treatment.

Researchers have uncovered why smell often fades early in Alzheimer’s: the brain’s immune cells dismantle key nerve connections between the olfactory bulb and brainstem. Membrane changes in neurons send an “eat-me” signal to microglia, which mistakenly destroy them. Evidence from mice, human tissue, and PET scans confirms this process. These insights could pave the way for earlier diagnosis and more effective treatment.

Scientists have uncovered a surprising new healing mechanism in injured cells called cathartocytosis, in which cells "vomit" out their internal machinery to revert more quickly to a stem cell-like state. While this messy shortcut helps tissues regenerate faster, it also leaves behind debris that can fuel inflammation and even cancer.

Harvard scientists have uncovered that lithium, a naturally occurring element in the brain, may be the missing piece in understanding Alzheimer’s. Their decade-long research shows that lithium depletion—caused by amyloid plaques binding to it—triggers early brain changes that lead to memory loss. By testing new lithium compounds that evade plaque capture, they reversed Alzheimer’s-like damage and restored memory in mice at doses far lower than those used in psychiatric treatments.

A Mediterranean-style diet was linked to lower dementia risk, especially in people with high-risk Alzheimer’s genes. The strongest benefits were seen in those with two APOE4 copies, showing diet may help offset genetic vulnerability. Researchers say food may influence key metabolic pathways that protect memory and cognitive function.

Knee osteoarthritis is a major cause of pain and disability, but routine X-rays often do more harm than good. New research shows that being shown an X-ray can increase anxiety, make people fear exercise, and lead them to believe surgery is the only option, even when less invasive treatments could help. By focusing on clinical diagnosis instead, patients may avoid unnecessary scans, reduce health costs, and make better choices about their care.

Painkillers we often trust — ibuprofen and acetaminophen — may be quietly accelerating one of the world’s greatest health crises: antibiotic resistance. Researchers discovered that these drugs not only fuel bacterial resistance on their own but make it far worse when combined with antibiotics. The findings are especially troubling for aged care settings, where residents commonly take multiple medications, creating perfect conditions for resistant bacteria to thrive.

University of Minnesota researchers developed a 3D-printed scaffold that directs stem cells to grow into functioning nerve cells, successfully restoring movement in rats with severed spinal cords. This promising technique could transform future treatment for spinal cord injuries.

St. Jude researchers revealed that midkine blocks amyloid beta from forming harmful clumps linked to Alzheimer’s. Without it, the damaging assemblies accelerate, but with it, growth halts. The finding could inspire new drugs that harness midkine’s protective power.

Researchers discovered that women with Alzheimer’s show a sharp loss of omega fatty acids, unlike men, pointing to sex-specific differences in the disease. The study suggests omega-rich diets could be key, but clinical trials are needed.

Researchers identified over 400 genes tied to various forms of frailty, offering fresh insight into why people age differently. The study highlights six distinct pathways of unhealthy aging, opening the door to more precise, targeted anti-aging interventions.

A large-scale review finds that acetaminophen use during pregnancy may increase the risk of autism and ADHD in children. The strongest studies showed the clearest links, pointing to biological pathways like oxidative stress and hormone disruption. Experts call for caution, updated guidelines, and safer alternatives.

In a health system where speed often replaces empathy, researchers highlight the life-changing power of listening. Beyond simple questions, values-driven listening—marked by presence, curiosity, and compassion—can transform both patients and providers.

A sweeping review of 67 trials has cast doubt on the use of ketamine and similar NMDA receptor antagonists for chronic pain relief. While ketamine is frequently prescribed off-label for conditions like fibromyalgia and nerve pain, researchers found little convincing evidence of real benefit and flagged serious side effects such as delusions and nausea. The lack of data on whether it reduces depression or opioid use adds to the uncertainty.